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J Med Microbiol 56 (2007), 1595-1599; DOI: 10.1099/jmm.0.47442-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Low concentrations of commercial alcohol hand rubs facilitate growth of and secretion of extracellular proteins by multidrug-resistant strains of Acinetobacter baumannii

Justin Edwards1, Geeta Patel2 and David W. Wareham1,3

1 Department of Medical Microbiology, Division of Infection, Barts and The London NHS Trust, Whitechapel, London E1 1BB, UK

2 Proteomics and Peptide Synthesis Facility, MRC Clinical Sciences Centre, Imperial College, Hammersmith Campus, London W12 0NN, UK

3 Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary's School of Medicine and Dentistry, London E1 2AT, UK

Correspondence
David W. Wareham
d.w.wareham{at}qmul.ac.uk

Received 11 June 2007
Accepted 3 August 2007

Acinetobacter baumannii is increasingly recognized as an important multidrug-resistant nosocomial pathogen. Recent work has highlighted enhanced growth and heightened virulence in the presence of ethyl alcohols. As alcohol-based hand rubs (ABHRs) are extensively used in health care settings, the authors set out to determine whether the hand rubs could also influence the growth of prevalent multidrug-resistant strains circulating in UK hospitals. A significant increase in growth was observed when minimal media were supplemented with concentrations of 1 % and lower of four commercially available hand rubs. In addition, growth in ABHR-supplemented media resulted in secretion of proteins into the culture supernatant. One of these was identified as OmpA, which is recognized as having emulsifying activity, which could potentially confer enhanced pathogenicity to A. baumannii.

Abbreviations: ABHRs, alcohol-based hand rubs; MDRAB, multidrug-resistant A. baumannii.






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