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J Med Microbiol 56 (2007), 1500-1504; DOI: 10.1099/jmm.0.47226-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Lactobacillus fermentum Ess-1 with unique growth inhibition of vulvo-vaginal candidiasis pathogens

Daniel Rönnqvist1, Ulla Forsgren-Brusk2, Ulrika Husmark2 and Eva Grahn-Håkansson3

1 Department of Clinical Bacteriology, Umeå University, Umeå, Sweden

2 SCA Hygiene Products AB, Gothenburg, Sweden

3 Essum AB, Umeå, Sweden

Correspondence
Daniel Rönnqvist
daniel.ronnqvist{at}essum.se

Received 12 February 2007
Accepted 3 July 2007

The aim of this study was to characterize human isolates of Lactobacillus species for their capacity to interfere with the growth of different strains of Candida species in vitro in the search for a potential probiotic. Growth inhibition of Candida species was screened using an agar-overlay method. Inhibiting strains were selected to assay the effect of a cell-free Lactobacillus culture filtrate (LCF) on the growth of isolates of Candida albicans and Candida glabrata. A total of 126 human Lactobacillus isolates was investigated. Eighteen isolates significantly inhibited the growth of C. albicans on agar. The LCF of one of these strains showed strong inhibition of both C. albicans and C. glabrata. This strain was genetically identified as Lactobacillus fermentum and designated L. fermentum Ess-1. Further tests to evaluate the probiotic potential of this strain indicated that L. fermentum Ess-1 strain is a promising probiotic for use in clinical trials to treat and prevent vulvo-vaginal candidiasis.

Abbreviations: LAB, lactic acid bacteria; LCF, Lactobacillus cell-free filtrate; VVC, vulvo-vaginal candidiasis.






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