J Med Microbiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ikumapayi, U. N.
Right arrow Articles by Adegbola, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ikumapayi, U. N.
Right arrow Articles by Adegbola, R. A.
Agricola
Right arrow Articles by Ikumapayi, U. N.
Right arrow Articles by Adegbola, R. A.
J Med Microbiol 56 (2007), 1479-1484; DOI: 10.1099/jmm.0.47416-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Molecular epidemiology of community-acquired invasive non-typhoidal Salmonella among children aged 2–29 months in rural Gambia and discovery of a new serovar, Salmonella enterica Dingiri

Usman N. Ikumapayi1, Martin Antonio1, Jacob Sonne-Hansen2, Ekow Biney1, Godwin Enwere1, Brown Okoko1, Claire Oluwalana1, Adeola Vaughan1, Syed M. A. Zaman1, Brian M. Greenwood3, Felicity T. Cutts1 and Richard A. Adegbola1

1 Medical Research Council Laboratories, Banjul, The Gambia, West Africa

2 Danish Salmonella Centre, Statens Serum Institute, Copenhagen, Denmark

3 London School of Hygiene and Tropical Medicine, Keppel Street, London, UK

Correspondence
Martin Antonio
mantonio{at}mrc.gm

Received 26 May 2007
Accepted 23 July 2007

Sixty-two invasive non-typhoidal Salmonella (NTS) isolates from children aged 2–29 months in rural Gambia were examined for serovar prevalence and antimicrobial susceptibility, and characterized using multilocus sequence typing (MLST) of seven genes, aroC, dnaN, hemD, hisD, purE, sucA and thrA. Salmonella enterica serovar Enteritidis was the most common serovar (80.6 %), followed by S. enterica serovar Typhimurium (8.0 %). Thirty-three per cent of the isolates were resistant to all eight antimicrobials tested, including ampicillin (74.2 %), cotrimoxazole (64.5 %) and tetracycline (63 %). A total of 40.3 % of the NTS cases had an initial clinical diagnosis of malaria, whilst 27.3 % had a diagnosis of clinical pneumonia and 18 % had a diagnosis of septicaemia. MLST of NTS resulted in ten different sequence types (STs), of which five were novel, representing five different NTS serovars. In general, STs were restricted to the same serovar. One type (ST11) encompassed 80.6 % of the NTSs. A new NTS serovar named S. enterica serovar Dingiri was discovered. S. Dingiri was isolated from a 6-month-old male with an initial clinical diagnosis of malaria but a final clinical diagnosis of anaemia and septicaemia. S. Dingiri, which possesses an antigenic formula of 17:z:1,6, was sensitive to ampicillin, cefotaxime, chloramphenicol, ciprofloxacin, cotrimoxazole and tetracycline but resistant to gentamicin, and was ST338.

Abbreviations: HIV, human immunodeficiency virus; MLST, multilocus sequence typing; NTS, non-typhoidal Salmonella; PVT, pneumococcal-conjugate vaccine trial; ST, sequence type.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2007 Society for General Microbiology.