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J Med Microbiol 56 (2007), 129-132; DOI: 10.1099/jmm.0.46549-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Case Report

Cerebral aspergillosis diagnosed by detection of Aspergillus flavus-specific DNA, galactomannan and (1->3)-ß-D-glucan in clinical specimens

Zia U. Khan1, Suhail Ahmad1, Eiman Mokaddas1, Tarek Said2, M. P. Nair2, M. A. Halim2, M. R. Nampoory2 and M. R. McGinnis3

1 Department of Microbiology, Faculty of Medicine, Kuwait University, Safat 13110, Kuwait

2 Hamed Al-Essa Organ Transplant Center, Kuwait

3 University of Texas Medical Branch, Department of Pathology, 301 University Boulevard, Galveston, Texas 77555-0609, USA

Correspondence
Zia U. Khan
ziauddin{at}hsc.edu.kw

Received 1 February 2006
Accepted 28 August 2006

A case of cerebral aspergillosis was diagnosed by the detection of Aspergillus flavus-specific DNA in brain biopsy and serum specimens. The diagnosis was also supported by detection of elevated levels of galactomannan and (1->3)-ß-D-glucan in serum specimens. Despite the presence of dichotomously branched septate hyphae in brain biopsy, the culture remained negative. The inability to isolate the organism in culture suggested that combined therapy of AmBisome and caspofungin was fungicidal for the fungus in the brain abscess.

Abbreviations: BAL, bronchoalveolar lavage; CNS, central nervous system; CT, computed tomography; IA, invasive aspergillosis.






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