J Med Microbiol International Journal of Systematic and Evolutionary Microbiology
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J Med Microbiol 55 (2006), 961-964; DOI: 10.1099/jmm.0.46394-0
© 2006 Society for General Microbiology
ISSN 1473-5644

Case Report

Microscopic, cultural and molecular evidence of disseminated invasive aspergillosis involving the lungs and the gastrointestinal tract

R. S. Jayshree1, M. Shafiulla1, J. George2, J. K. David3, P. P. Bapsy2 and A. Chakrabarti3

1 ,2 Departments of Microbiology1 and Medical Oncology2 , Kidwai Memorial Institute of Oncology, Bangalore-560 029, India

3 Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh-160 012, India

Correspondence
R. S. Jayshree
jayshre{at}bgl.vsnl.net.in

Received 2 November 2005
Accepted 24 March 2006

A patient with acute promyelocytic leukaemia developed invasive aspergillosis post chemotherapy during a pancytopenic episode, clinically involving the lungs and the gastrointestinal tract. Dichotomously branched septate fungal hyphae were demonstrated microscopically in stools and sputa. Cultures of the samples yielded Aspergillus flavus, which were identical by RFLP and random amplification of polymorphic DNA analyses and antifungal MICs, proving disseminated disease. To the best of the author's knowledge, this is the first time that boluses of fungal hyphae have been demonstrated microscopically in the stools of a patient with gastrointestinal aspergillosis.

Abbreviations: GIA, gastrointestinal aspergillosis; GIT, gastrointestinal tract; IA, invasive aspergillosis; IFI, invasive fungal infection; RAPD, random amplification of polymorphic DNA.






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