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J Med Microbiol 55 (2006), 871-877; DOI: 10.1099/jmm.0.46441-0
© 2006 Society for General Microbiology
ISSN 1473-5644

Molecular characterization of antimicrobial resistance in Shigella sonnei isolates in Korea

Sung Yong Seol, Yong Tae Kim, Young Sook Jeong, Jae Young Oh, Hee Young Kang, Dong Chan Moon, Jungmin Kim, Yoo Chul Lee, Dong Taek Cho and Je Chul Lee

Department of Microbiology, Kyungpook National University School of Medicine, 101, Dongin-dong, Jung-gu, Daegu, 700-422, Korea

Correspondence
Je Chul Lee
leejc{at}knu.ac.kr

Received 29 November 2005
Accepted 23 March 2006

The antimicrobial resistance of 122 Shigella sonnei isolates obtained in Korea during the period 1991–2000 was characterized. These isolates were highly resistant to traditional antibiotics such as trimethoprim (100 %), streptomycin (100 %), sulfamethoxazole (94 %), tetracycline (93 %) and nalidixic acid (90 %). All S. sonnei isolates carried Tn7 in their chromosomes. The 8.4 kb non-transferable resistance (R) plasmid carrying tetA, strA-strB and sul1 was found in 93 % of the S. sonnei isolates. Resistance to nalidixic acid first appeared in a S. sonnei isolate in 1997, and then in all S. sonnei isolates from 1998 and 1999. Resistance to commonly prescribed antibiotics such as ampicillin was increased in S. sonnei isolates during the outbreak period 1998–2000. Resistance to ampicillin was mediated by the conjugative R plasmids carrying blaTEM-1. In conclusion, S. sonnei acquired antimicrobial resistance to commonly prescribed antibiotics through the horizontal transfer of conjugative R plasmids, while the genetic stability of transposon and non-transferable R plasmids was responsible for resistance to traditional antibiotics.

Abbreviations: ESBL, extended-spectrum ß-lactamase; R plasmid, resistance plasmid.




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