J Med Microbiol International Journal of Systematic and Evolutionary Microbiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Enoch, D. A.
Right arrow Articles by Brown, N. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Enoch, D. A.
Right arrow Articles by Brown, N. M.
Agricola
Right arrow Articles by Enoch, D. A.
Right arrow Articles by Brown, N. M.
J Med Microbiol 55 (2006), 809-818; DOI: 10.1099/jmm.0.46548-0
© 2006 Society for General Microbiology
ISSN 1473-5644

Review

Invasive fungal infections: a review of epidemiology and management options

D. A. Enoch, H. A. Ludlam and N. M. Brown

Clinical Microbiology and Public Health Laboratory, Health Protection Agency, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QW, UK

Correspondence
D. A. Enoch
david.enoch{at}addenbrookes.nhs.uk


Fungi are increasingly recognised as major pathogens in critically ill patients. Candida spp. and Cryptococcus spp. are the yeasts most frequently isolated in clinical practice. The most frequent filamentous fungi (moulds) isolated are Aspergillus spp., but Fusarium spp., Scedosporium spp., Penicillium spp., and Zygomycetes are increasingly seen. Several reasons have been proposed for the increase in invasive fungal infections, including the use of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics, and prosthetic devices and grafts, and more aggressive surgery. Patients with burns, neutropenia, HIV infection and pancreatitis are also predisposed to fungal infection. The epidemiology and clinical features of fungal infections are reviewed, together with antifungal agents currently or soon to be available.




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Uchida, G. McDermott, M. Wetzler, M. A. Le Gros, M. Myllys, C. Knoechel, A. E. Barron, and C. A. Larabell
Soft X-ray tomography of phenotypic switching and the cellular response to antifungal peptoids in Candida albicans
PNAS, November 17, 2009; 106(46): 19375 - 19380.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
M. Harris, H. M. Mora-Montes, N. A. R. Gow, and P. J. Coote
Loss of mannosylphosphate from Candida albicans cell wall proteins results in enhanced resistance to the inhibitory effect of a cationic antimicrobial peptide via reduced peptide binding to the cell surface
Microbiology, April 1, 2009; 155(4): 1058 - 1070.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
C. Landlinger, S. Preuner, B. Willinger, B. Haberpursch, Z. Racil, J. Mayer, and T. Lion
Species-Specific Identification of a Wide Range of Clinically Relevant Fungal Pathogens by Use of Luminex xMAP Technology
J. Clin. Microbiol., April 1, 2009; 47(4): 1063 - 1073.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. E. Cowen, S. D. Singh, J. R. Kohler, C. Collins, A. K. Zaas, W. A. Schell, H. Aziz, E. Mylonakis, J. R. Perfect, L. Whitesell, et al.
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
PNAS, February 24, 2009; 106(8): 2818 - 2823.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. Kitamura, K. Someya, M. Hata, R. Nakajima, and M. Takemura
Discovery of a Small-Molecule Inhibitor of {beta}-1,6-Glucan Synthesis
Antimicrob. Agents Chemother., February 1, 2009; 53(2): 670 - 677.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
P. M. Tavares, K. Thevissen, B. P. A. Cammue, I. E. J. A. Francois, E. Barreto-Bergter, C. P. Taborda, A. F. Marques, M. L. Rodrigues, and L. Nimrichter
In Vitro Activity of the Antifungal Plant Defensin RsAFP2 against Candida Isolates and Its In Vivo Efficacy in Prophylactic Murine Models of Candidiasis
Antimicrob. Agents Chemother., December 1, 2008; 52(12): 4522 - 4525.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
X. Zhou, F. Kong, T. C. Sorrell, H. Wang, Y. Duan, and S. C. A. Chen
Practical Method for Detection and Identification of Candida, Aspergillus, and Scedosporium spp. by Use of Rolling-Circle Amplification
J. Clin. Microbiol., July 1, 2008; 46(7): 2423 - 2427.
[Abstract] [Full Text] [PDF]

Home page
 Clin Med ResHome page
P. M. Neal and A. Nikolai
Systemic Blastomycosis Diagnosed by Prostate Needle Biopsy
Clin. Med. Res., May 1, 2008; 6(1): 24 - 28.
[Abstract] [Full Text] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
A. M. Dranginis, J. M. Rauceo, J. E. Coronado, and P. N. Lipke
A Biochemical Guide to Yeast Adhesins: Glycoproteins for Social and Antisocial Occasions
Microbiol. Mol. Biol. Rev., June 1, 2007; 71(2): 282 - 294.
[Abstract] [Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
C. Eiden, H. Peyriere, M. Cociglio, S. Djezzar, S. Hansel, J.-P. Blayac, D. Hillaire-Buys, and for the Network of the French Pharmacovigilance Ce
Adverse Effects of Voriconazole: Analysis of the French Pharmacovigilance Database
Ann. Pharmacother., May 1, 2007; 41(5): 755 - 763.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2006 Society for General Microbiology.