J Med Microbiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cermelli, C.
Right arrow Articles by Blasi, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cermelli, C.
Right arrow Articles by Blasi, E.
Agricola
Right arrow Articles by Cermelli, C.
Right arrow Articles by Blasi, E.
J Med Microbiol 55 (2006), 695-702; DOI: 10.1099/jmm.0.46496-0
© 2006 Society for General Microbiology
ISSN 1473-5644

Human herpesvirus-6 dysregulates monocyte-mediated anticryptococcal defences

Claudio Cermelli1, Valeria Cenacchi1, Francesca Beretti1, Francesco Pezzini1, Dario Di Luca2 and Elisabetta Blasi1

1 Department of Hygiene, Microbiology and Biostatistics, University of Modena and Reggio Emilia, Via Campi 287, I-41100 Modena, Italy

2 Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy

Correspondence
Claudio Cermelli
c.cermelli{at}unimo.it

Received 3 January 2006
Accepted 17 February 2006

In order to investigate the interplay occurring between pathogens in the course of double infections, an in vitro model was set up in which the monocytic cell line THP-1 was exposed to Cryptococcus neoformans (Cn) and human herpesvirus 6 (HHV-6). Cn and HHV-6, both highly neurotropic, can cause serious diseases of the central nervous system and have monocytes, among other cell types, as target cells, causing alteration of their secretion pattern. Here, it was shown that unlike THP-1 cells exposed to cell-free virus inocula, THP-1 exposed to HHV-6-producing lymphocytes exhibited augmented phagocytosis against Cn. The phenomenon occurred after 24 h of monocyte/lymphocyte co-culture and was independent of direct cell-to-cell contact. Moreover, in the presence of HHV-6, THP-1 cells expressed enhanced secretory responses but reduced capability to counteract fungal infection: the enhanced ingestion by monocytes was followed by facilitated fungal survival and replication. These data provide initial in vitro evidence that HHV-6 may dysregulate monocyte-mediated anticryptococcal defences with an overall pro-cryptococcus result.

Abbreviations: Cn, Cryptococcus neoformans; CNS, central nervous system; CPE, cytopathic effect; HHV-6, human herpesvirus-6; IFA, immunofluorescence assay; IHC, immunohistochemistry.




This article has been cited by other articles:


Home page
 J Med MicrobiolHome page
R. Micol, P. Buchy, J. Galimand, D. Veasna, L. Ferradini, S. Balkan, P. J. Guerin, P.-R. Martin, A. Fontanet, O. Lortholary, et al.
No association between human herpesvirus 6 reactivation and cryptococcosis in human immunodeficiency virus-infected patients
J. Med. Microbiol., February 1, 2009; 58(2): 276 - 277.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2006 Society for General Microbiology.