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J Med Microbiol 55 (2006), 635-638; DOI: 10.1099/jmm.0.46398-0
© 2006 Society for General Microbiology
ISSN 1473-5644

Case Report

Aspergillus fumigatus tricuspid native valve endocarditis in a non-intravenous drug user

Antonios Vassiloyanakopoulos1, Matthew E. Falagas1,2,3, Maria Allamani4 and Argyris Michalopoulos2,5

1 ,4 ,5 Department of Medicine1 , Pathology Department4 and Intensive Care Unit5 , Henry Dunant Hospital, Athens, Greece

2 Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece

3 Department of Medicine, Tufts University School of Medicine, Boston, MA, USA

Correspondence
Argyris Michalopoulos
amichalopoulos{at}hol.gr

Received 3 November 2005
Accepted 30 December 2005

Invasive aspergillosis is an emerging infection mainly affecting immunocompromised patients. This report details a case of Aspergillus fumigatus tricuspid native valve endocarditis complicated by recurrent septic pulmonary emboli in a young, non-intravenous drug user. He was treated by surgical resection of the posterior leaflet of the tricuspid valve and the vegetations, as well as by valvuloplasty, which was followed by a combination of liposomal amphotericin B and voriconazole as acute-phase therapy and voriconazole alone as suppression therapy.




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