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J Med Microbiol 55 (2006), 355-363; DOI: 10.1099/jmm.0.46423-0
© 2006 Society for General Microbiology
ISSN 0022-2615

Review

Role of two-component systems in the virulence of Streptococcus pneumoniae

G. K. Paterson, C. E. Blue and T. J. Mitchell

Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK

Correspondence
T. J. Mitchell
t.mitchell{at}bio.gla.ac.uk


Understanding of how the human pathogen Streptococcus pneumoniae perceives and responds to its environment in the host offers insight into the pathogenesis of disease caused by this important bacterium and the potential for improved interventions. A central role in this environmental response is played by two-component systems (TCSs), which both sense the environment and drive the cellular response. Molecular advances in the form of genome sequencing, signature-tagged mutagenesis, differential fluorescence induction and microarray analysis have yielded considerable progress in the study of these systems in S. pneumoniae. These recent advances are discussed here, focusing in particular on the role of TCSs in the virulence of S. pneumoniae.




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