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J Med Microbiol 55 (2006), 341-343; DOI: 10.1099/jmm.0.46337-0
© 2006 Society for General Microbiology
ISSN 0022-2615

Case Report

Severe case of Mediterranean spotted fever in Greece with predominantly neurological features

Konstantina Tzavella1, Ioannis S. Hatzizisis1, Aikaterini Vakali2, Kalliopi Mandraveli3, Dimitrios Zioutas4 and Stella Alexiou-Daniel3

First Propedeutic Medical Department1 , Department of Radiology2 , First Department of Microbiology3 and Department of Cardiology4 , AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

Correspondence
Konstantina Tzavella
ktzavell{at}med.auth.gr

Received 19 September 2005
Accepted 29 October 2005

Rickettsia conorii is endemic in Greece, though only a few cases of infection have been published to date. The case of a 58-year-old man from northern Greece with a severe form of Mediterranean spotted fever and rapid neurological deterioration is presented here. The patient received antibiotic treatment with doxycycline, showing immediate clinical and laboratory improvement. Diagnosis was confirmed later, during the second week after disease onset, by detection of elevated titres of IgM and IgG antibodies against R. conorii using an indirect immunofluorescence assay.




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