J Med Microbiol International Journal of Systematic and Evolutionary Microbiology
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J Med Microbiol 55 (2006), 171-178; DOI: 10.1099/jmm.0.46149-0
© 2006 Society for General Microbiology
ISSN 0022-2615

Serological diagnosis of Trypanosoma cruzi: evaluation of three enzyme immunoassays and an indirect immunofluorescent assay

Annette K. Malan1, Erick Avelar2, Sheldon E. Litwin2, Harry R. Hill1,3 and Christine M. Litwin1,3

1 University of Utah, Associated Regional and University Pathologists (ARUP) Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA

2 ,3 Department of Medicine, Division of Cardiology2 and Departments of Pathology, Pediatrics and Medicine3 , University of Utah School of Medicine, Salt Lake City, Utah, USA

Correspondence
Christine M. Litwin
christine.litwin{at}path.utah.edu

Received 6 May 2005
Accepted 30 September 2005

Chagas' disease is an important cause of heart failure in Latin America, but is rare in the United States. The immigration of persons from endemic countries increases the potential of encountering patients with the disease. Concerns have also been raised about the introduction of Trypanosoma cruzi, the parasite that causes the disease, into the blood supply and during organ transplantation. To compare Chagas' antibody tests that are available in the United States, we evaluated three IgG ELISAs, CeLLabs T. cruzi ELISA, Hemagen Chagas' kit and IVD Research Chagas' Serum Microwell ELISA, and MarDx indirect immunofluorescent assays. The CeLLabs and Hemagen IgG ELISAs had 100 % agreement, sensitivity and specificity. The IVD Research IgG ELISA had 94·6 % agreement, 100 % sensitivity and 93 % specificity.

Abbreviations: ECG, electrocardiogram; EIA, enzyme immunoassay; FDA, Food and Drug Administration; IFA, immunofluorescent assay; SLE, systemic lupus erythematosus.




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Z. C. Caballero, O. E. Sousa, W. P. Marques, A. Saez-Alquezar, and E. S. Umezawa
Evaluation of Serological Tests To Identify Trypanosoma cruzi Infection in Humans and Determine Cross-Reactivity with Trypanosoma rangeli and Leishmania spp.
Clin. Vaccine Immunol., August 1, 2007; 14(8): 1045 - 1049.
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