J Med Microbiol NEW Faster Access
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Linke, M.
Right arrow Articles by Walzer, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Linke, M.
Right arrow Articles by Walzer, P.
Agricola
Right arrow Articles by Linke, M.
Right arrow Articles by Walzer, P.
J Med Microbiol 55 (2006), 143-147; DOI: 10.1099/jmm.0.46190-0
© 2006 Society for General Microbiology
ISSN 0022-2615

Efficient resolution of Pneumocystis murina infection in surfactant protein A-deficient mice following withdrawal of corticosteroid-induced immunosuppression

Michael Linke1,2, Alan Ashbaugh2, Judith Koch2, Reiko Tanaka2 and Peter Walzer1,2

1 Department of Veterans Affairs Medical Center, Research Service, 3200 Vine St, Cincinnati, OH 45220, USA

2 University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Infectious Diseases, 231 Bethesda, Cincinnati, OH 45221, USA

Correspondence
Michael Linke
Michael.Linke{at}med.va.gov

Received 5 June 2005
Accepted 7 October 2005

Following withdrawal of immunosuppression, surfactant protein A (SP-A)-deficient and wild-type mice cleared Pneumocystis murina infection in a similar manner, but exhibited significant differences in lymphocyte populations, interleukin (IL)-6 levels and chemokine expression levels. A higher percentage of lymphocytes were detected in lung lavage fluid from SP-A-deficient mice, but more CD4+ T cells were isolated from lung tissue of wild-type mice. Higher concentrations of IL-6 were detected in lavage fluid and enhanced expression of lymphotactin and RANTES were detected in the lungs of wild-type mice. Equal levels of surfactant protein D were detected in SP-A-deficient and wild-type mice and no differences were detected in markers of lung injury between the two strains of mice. Thus, SP-A does not enhance organism clearance, but does modulate the host immune response during resolution of P. murina infection.

Abbreviations: DEX, dexamethasone; Ltn, lymphotactin; PcP, Pneumocystis pneumonia; RPA, ribonuclease protection assay; SP-A, surfactant protein A; SP-D, surfactant protein D.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2006 Society for General Microbiology.