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J Med Microbiol 55 (2006), 139-142; DOI: 10.1099/jmm.0.46206-0
© 2006 Society for General Microbiology
ISSN 0022-2615

Virulence profile of strains of Cryptococcus neoformans var. grubii evaluated by experimental infection in BALB/c mice and correlation with exoenzyme activity

Eriques Gonçalves da Silva1, Francisco de Assis Baroni2, Flavio César Viani1, Luciana da Silva Ruiz1, Rinaldo Ferreira Gandra3, Marcos Ereno Auler1, Amanda Latércia Tranches Dias1, Walderez Gambale1 and Claudete Rodrigues Paula1

1 Instituto Ciências Biomédicas, Departamento de Microbiologia, Seção de Micologia, Laboratório de Leveduras Patogênicas, Universidade de São Paulo, Av. Professor Lineu Prestes, 1374, Cidade Universitária, CEP 05508-900, São Paulo, Brazil

2 Universidade Federal Rural do Rio de Janeiro, UFRRJ, Rio de Janeiro, Brazil

3 Universidade Estadual do Oeste do Paraná, UNIOESTE, Cascavel, Paraná, Brazil

Correspondence
Claudete Rodrigues Paula
crpmicol{at}uol.com.br

Received 18 June 2005
Accepted 13 October 2005

To evaluate the virulence profile of strains of Cryptococcus neoformans var. grubii, 62 strains of this yeast were inoculated into BALB/c mice. It was found that 69 % of the strains were significantly more lethal to the mice and were recovered from a higher percentage (60 %) of the organs compared with the other 31 % of the strains, which were recovered from 35 % of organs tested. Those strains that provoked higher death rates were also recovered from the central nervous system at a higher rate (84 %) than the less lethal strains (32 %). This finding led to an investigation of the factors that enhanced the capacity for neurological infection and death of the animals. The results of this study suggested that environmental strains present different degrees of virulence. The correlation of exoenzyme production before and after inoculation and between the groups of mice indicated that exoenzyme production had no influence on differences in virulence among the strains studied.




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 Infect. Immun.Home page
A. P. Litvintseva and T. G. Mitchell
Most Environmental Isolates of Cryptococcus neoformans var. grubii (Serotype A) Are Not Lethal for Mice
Infect. Immun., August 1, 2009; 77(8): 3188 - 3195.
[Abstract] [Full Text] [PDF]


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