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J Med Microbiol 55 (2006), 1457-1459; DOI: 10.1099/jmm.0.46639-0
© 2006 Society for General Microbiology
ISSN 1473-5644

Case Report

Use of voriconazole in a patient with aspergilloma caused by an itraconazole-resistant strain of Aspergillus fumigatus

E. Dannaoui1,2, D. Garcia-Hermoso1, J. M. Naccache3, I. Meneau4, D. Sanglard4, C. Bouges-Michel5, D. Valeyre3 and O. Lortholary1,6

1 Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS FRE2849, Institut Pasteur, 75724 Paris Cedex 15, France

2 Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Européen Georges Pompidou, Unité de Parasitologie – Mycologie, 75015 Paris, France

3 Service de Pneumologie, Hôpital Avicenne, 93009 Bobigny, France

4 Institute of Microbiology, University Hospital Lausanne, CH-1011 Lausanne, Switzerland

5 Laboratoire de Parasitologie-Mycologie, Hôpital Avicenne, 93009 Bobigny, France

6 Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Necker-Enfants-Malades, Service des Maladies Infectieuses et Tropicales, 75743 Paris Cedex 15, France

Correspondence
E. Dannaoui
dannaoui{at}pasteur.fr

Received 22 March 2006
Accepted 10 July 2006

The case is reported of a patient with cavitary sarcoidosis complicated by an aspergilloma caused by an itraconazole-resistant strain of Aspergillus fumigatus, who was treated with voriconazole. The authors suggest that susceptibility testing of A. fumigatus strains is of value during long-term therapy with itraconazole, and that voriconazole may be a good option for treatment of patients infected with itraconazole-resistant strains of A. fumigatus.




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