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J Med Microbiol 55 (2006), 1447-1451; DOI: 10.1099/jmm.0.46615-0
© 2006 Society for General Microbiology
ISSN 1473-5644

Optimal sampling site for mucosal candidosis in oral cancer patients is the labial sulcus

Riina Rautemaa1,2,3, Peter Rusanen1,4, Malcolm Richardson1,3 and Jukka H. Meurman2,4

1 Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland

2 Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital (HUCH), Helsinki, Finland

3 Microbiology Unit of Helsinki University Central Hospital (HUCH) Laboratory Diagnostics, Helsinki, Finland

4 Institute of Dentistry, University of Helsinki, Helsinki, Finland

Correspondence
Riina Rautemaa
riina.richardson{at}helsinki.fi

Received 8 March 2006
Accepted 13 July 2006

Traditional sampling methods for the diagnosis of oral candidosis in head and neck cancer patients, i.e. saliva collection or tongue scrapings, are often impossible to perform. The aim was to determine the optimal sampling method. Eighteen oral cancer patients and five control subjects were sampled semi-quantitatively from the labial sulcus, dorsum of the tongue, dental plaque and saliva for cultivation of yeasts. The patients were examined prior to all cancer treatment (n=5), or 2–4 weeks (n=5) or 8–12 weeks (n=8) post-operatively. The incidence of Candida was found to increase from 40 % at the control and pre-operative level up to 73 % 8–12 weeks post-operatively. Candida albicans was found to be the only species until 4 weeks post-operatively. Thereafter, the incidence of species other than C. albicans was 38 %. The most sensitive sampling site was found to be the vestibular sulcus, from which all culture-positive cases could be confirmed. Tongue surface scraping was found to be more sensitive than saliva collection in detecting Candida. All sampling methods and sites were equally sensitive in detecting the different Candida species. Dental plaque was found to have the highest density of Candida colonization, and was thus found to be the most significant source of Candida infection, which emphasizes the role of dental care in these patients.




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R. Rautemaa, M. Richardson, M. Pfaller, P. Koukila-Kahkola, J. Perheentupa, and H. Saxen
Decreased susceptibility of Candida albicans to azole antifungals: a complication of long-term treatment in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients
J. Antimicrob. Chemother., October 1, 2007; 60(4): 889 - 892.
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