J Med Microbiol Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, W.-B.
Right arrow Articles by Liaw, S.-J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, W.-B.
Right arrow Articles by Liaw, S.-J.
Agricola
Right arrow Articles by Wang, W.-B.
Right arrow Articles by Liaw, S.-J.
J Med Microbiol 55 (2006), 1313-1321; DOI: 10.1099/jmm.0.46661-0
© 2006 Society for General Microbiology
ISSN 1473-5644

Inhibition of swarming and virulence factor expression in Proteus mirabilis by resveratrol

Won-Bo Wang1, Hsin-Chih Lai2,3, Po-Ren Hsueh3, Robin Y.-Y. Chiou4, Shwu-Bin Lin2,3 and Shwu-Jen Liaw2,3

1 ,2 Graduate Institute of Microbiology1 and Department and Graduate Institute of Clinical Laboratory Sciences and Medical Biotechnology2 , College of Medicine, National Taiwan University, 10016 no. 1 Chang-Te Street, Taipei, Taiwan, Republic of China

3 Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan, Republic of China

4 Department of Food Science, National Chiayi University, Chiayi, Taiwan, Republic of China

Correspondence
Shwu-Jen Liaw
s-jliaw{at}ha.mc.ntu.edu.tw

Received 4 April 2006
Accepted 3 July 2006

Resveratrol (3,5,4-trihydroxy-trans-stilbene) is a phytoalexin compound with anti-inflammatory and antioxidant activities. The effect of resveratrol on swarming and virulence factor expression of Proteus mirabilis, an important pathogen infecting the urinary tract, was determined on swarming agar plates with and without the compound. Bacteria harvested at different times were assayed for cell length and the production of flagella, haemolysin and urease. Resveratrol inhibited P. mirabilis swarming and virulence factor expression in a dose-dependent manner. Resveratrol significantly inhibited swarming at 15 µg ml–1, and completely inhibited swarming at 60 µg ml–1. Inhibition of swarming and virulence factor expression was mediated through RsbA, a His-containing phosphotransmitter of the bacterial two-component signalling system possibly involved in quorum sensing. Complementation of an rsbA-defective mutant with the rsbA gene restored its responsiveness to resveratrol. The compound also inhibited the ability of P. mirabilis to invade human urothelial cells. These findings suggest that resveratrol has potential to be developed as an antimicrobial agent against P. mirabilis infection.

Abbreviations: QS, quorum sensing; resveratrol, 3,5,4-trihydroxy-trans-stilbene; ROS, reactive oxygen species.




This article has been cited by other articles:


Home page
 Infect. Immun.Home page
W.-B. Wang, I-C. Chen, S.-S. Jiang, H.-R. Chen, C.-Y. Hsu, P.-R. Hsueh, W.-B. Hsu, and S.-J. Liaw
Role of RppA in the Regulation of Polymyxin B Susceptibility, Swarming, and Virulence Factor Expression in Proteus mirabilis
Infect. Immun., May 1, 2008; 76(5): 2051 - 2062.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
C.-C. Lu, H.-C. Lai, S.-C. Hsieh, and J.-K. Chen
Resveratrol ameliorates Serratia marcescens-induced acute pneumonia in rats
J. Leukoc. Biol., April 1, 2008; 83(4): 1028 - 1037.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
J. J. Docherty, H. A. McEwen, T. J. Sweet, E. Bailey, and T. D. Booth
Resveratrol inhibition of Propionibacterium acnes
J. Antimicrob. Chemother., June 1, 2007; 59(6): 1182 - 1184.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2006 Society for General Microbiology.