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J Med Microbiol 54 (2005), 803-804; DOI: 10.1099/jmm.0.46060-0
© 2005 Society for General Microbiology
ISSN 0022-2615

Chorioamnionitis associated with Crohn's disease and azathioprine treatment: a case report

Limor Helpman, David Pauzner, Joseph B Lessing, Michael J Kupferminc and Guy Gutman

Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Correspondence Guy Gutman gutguy10{at}yahoo.com

Received February 26, 2005
Accepted May 14, 2005

This paper reports a case of S. constellatus chorioamnionitis in a pregnant Crohn's disease patient who was taking azathioprine. Chorioamnionitis is a major cause of perinatal morbidity. Azathioprine, an immunosuppressive antimetabolite, is widely used to treat inflammatory bowel disease. Streptococcus constellatus is a Gram-positive bacterium that has not previously been associated with chorioamnionitis. A high index of suspicion for chorioamnionitis and unusual pathogens should be maintained in the management of obstetric patients on immunosuppressive agents.






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