HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Maghsood, A. H. Articles by Khan, N. A. Search for Related Content PubMed PubMed Citation Articles by Maghsood, A. H. Articles by Khan, N. A. Agricola Articles by Maghsood, A. H. Articles by Khan, N. A.

Acanthamoeba genotype T4 from the UK and Iran and isolation of the T2 genotype from clinical isolates

¹School of Biological and Chemical Sciences, Birkbeck College, University of London, London WC1E 7HX, UK ²Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, 14155-6446, Iran ³Diagnostic Parasitology Laboratory, London School of Hygiene and Tropical Medicine, London, UK

Correspondence Naveed Ahmed Khan n.khan{at}sbc.bbk.ac.uk

Received November 30, 2004
Accepted March 15, 2005

The majority of the keratitis-causing Acanthamoeba isolates are genotype T4. In an attempt to determine whether predominance of T4 isolates in Acanthamoeba keratitis is due to greater virulence or greater prevalence of this genotype, Acanthamoeba genotypes were determined for 13 keratitis isolates and 12 environmental isolates from Iran. Among 13 clinical isolates, eight (61.5 %) belonged to T4, two (15.3 %) belonged to T3 and three (23 %) belonged to the T2 genotype. In contrast, the majority of 12 environmental isolates tested in the present study belonged to T2 (7/12, 58.3 %), followed by 4/12 T4 isolates (33.3 %). In addition, the genotypes of six new Acanthamoeba isolates from UK keratitis cases were determined. Of these, five (83.3 %) belonged to T4 and one was T3 (16.6 %), supporting the expected high frequency of T4 in Acanthamoeba keratitis. In total, the genotypes of 24 Acanthamoeba keratitis isolates from the UK and Iran were determined. Of these, 17 belonged to T4 (70.8 %), three belonged to T2 (12.5 %), three belonged to T3 (12.5 %) and one belonged to T11 (4.1 %), confirming that T4 is the predominant genotype (S² = 4.167; P = 0.0412) in Acanthamoeba keratitis.

This article has been cited by other articles:

				C. M. Martin-Navarro, J. Lorenzo-Morales, M. G. Cabrera-Serra, F. Rancel, N. M. Coronado-Alvarez, J. E. Pinero, and B. Valladares The potential pathogenicity of chlorhexidine-sensitive Acanthamoeba strains isolated from contact lens cases from asymptomatic individuals in Tenerife, Canary Islands, Spain J. Med. Microbiol., November 1, 2008; 57(11): 1399 - 1404. [Abstract] [Full Text] [PDF]

				J. Matsuo, Y. Hayashi, S. Nakamura, M. Sato, Y. Mizutani, M. Asaka, and H. Yamaguchi Novel Parachlamydia acanthamoebae Quantification Method Based on Coculture with Amoebae Appl. Envir. Microbiol., October 15, 2008; 74(20): 6397 - 6404. [Abstract] [Full Text] [PDF]

				J. Walochnik, A. Aichelburg, O. Assadian, A. Steuer, G. Visvesvara, N. Vetter, and H. Aspock Granulomatous Amoebic Encephalitis Caused by Acanthamoeba Amoebae of Genotype T2 in a Human Immunodeficiency Virus-Negative Patient J. Clin. Microbiol., January 1, 2008; 46(1): 338 - 340. [Abstract] [Full Text] [PDF]

				J. Lorenzo-Morales, N. Coronado-Alvarez, E. Martinez-Carretero, S. K. Maciver, and B. Valladares Detection of Four Adenovirus Serotypes within Water-Isolated Strains of Acanthamoeba in the Canary Islands, Spain Am J Trop Med Hyg, October 1, 2007; 77(4): 753 - 756. [Abstract] [Full Text] [PDF]