J Med Microbiol Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yordanov, M
Right arrow Articles by Ivanovska, N
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yordanov, M
Right arrow Articles by Ivanovska, N
Agricola
Right arrow Articles by Yordanov, M
Right arrow Articles by Ivanovska, N
J Med Microbiol 54 (2005), 647-653; DOI: 10.1099/jmm.0.45919-0
© 2005 Society for General Microbiology
ISSN 0022-2615

Ibogaine reduces organ colonization in murine systemic and gastrointestinal Candida albicans infections

M Yordanov1, P Dimitrova1, S Patkar2, S Falcocchio3, E Xoxi3, L Saso3 and N Ivanovska1

1Department of Immunology, Institute of Microbiology, 26 G. Bonchev Str., 1113 Sofia, Bulgaria 2Novozymes A/S, Novo Allé, DK-2880, Bagsvaerd, Denmark 3Department of Human Physiology and Pharmacology ‘Vittorio Erspame', University of Rome ‘La Sapienza', P. le Aldo Moro 5, 00185 Rome, Italy

Correspondence N. Ivanovska nina{at}microbio.bas.bg

Received October 7, 2004
Accepted March 1, 2005

In the present study the effect of the indole alkaloid ibogaine on the in vitro lipolytic activity and adherence to epithelial cells of Candida albicans was investigated. The substance was administered intraperitoneally at a dose of 5 mg kg–1 day–1 in mice with disseminated and gastrointestinal C. albicans infections. Ibogaine significantly decreased the rate of mortality and the number of C. albicans c.f.u. recovered from the kidney, liver and spleen. Ibogaine interfered with the early stages of both disseminated and gastrointestinal C. albicans infections but did not reduce the number of C. albicans c.f.u. in the organs at the late phase of infections. The development of a specific immune response was not influenced by ibogaine, since the delayed-type hypersensitivity reaction to C. albicans and the production of interferon (IFN)-{gamma} were similar in control and ibogaine-treated mice. The combined use of amphotericin B plus ibogaine in the treatment of mice with gastrointestinal infection reduced organ colonization more strongly than each substance alone.

Abbreviations: AmB, amphotericin B; DTH, delayed-type hypersensitivity reaction; IFN, interferon; i.v., intravenously.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2005 Society for General Microbiology.