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J Med Microbiol 54 (2005), 549-552; DOI: 10.1099/jmm.0.45968-0
© 2005 Society for General Microbiology
ISSN 0022-2615

In vitro antifungal activity of 2-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1-methylethyl pentanoate, a dihydropyrrole derivative

Rajesh Dabur1, A K Chhillar2, V Yadav2, Pradeep K Kamal1, J Gupta2 and G L Sharma1

1Department of Biomedical Sciences, Bundelkhand University, Jhansi, India 2Institute of Genomics and Integrative Biology, Mall Road, Delhi, India

Correspondence Rajesh Dabur rajeshdabur{at}yahoo.com

Received November 25, 2004
Accepted February 7, 2005

A novel compound 2-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1-methylethyl pentanoate was isolated from the plant Datura metel L. The in vitro activity of this dihydropyrrole derivative against Aspergillus and Candida species was evaluated by using standard methods approved by the National Committee for Clinical Laboratory Standards. The compound was found to be active against all the species tested, namely Candida albicans, Candida tropicalis, Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger. The MIC at which more than 90 % of growth was inhibited (MIC90) by the compound ranged from 21.87 to 43.75 µg ml–1 against various fungal species by microbroth dilution assay. Since the compound 2-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1-methylethyl pentanoate has antifungal activity it can be explored further to develop new antimycotic drugs.

Abbreviation: NCCLS, National Committee for Clinical Laboratory Standards.




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R. Dabur, T. K. Mandal, and G. L. Sharma
Post-antifungal effects of the antifungal compound 2-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1-methylethyl pentanoate on Aspergillus fumigatus
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An antifungal protein from Escherichia coli
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