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J Med Microbiol 54 (2005), 515-518; DOI: 10.1099/jmm.0.46004-0
© 2005 Society for General Microbiology
ISSN 0022-2615

Role of Pseudomonas aeruginosa quorum-sensing systems in a mouse model of chronic respiratory infection

Yoshifumi Imamura{dagger}, Katsunori Yanagihara{dagger}, Kazunori Tomono, Hideaki Ohno, Yasuhito Higashiyama, Yoshitsugu Miyazaki, Yoichi Hirakata, Yohei Mizuta, Jun-ichi Kadota, Kazuhiro Tsukamoto and Shigeru Kohno

Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan

Correspondence Katsunori Yanagihara kyana-ngs{at}umin.ac.jp

Received January 4, 2005
Accepted February 17, 2005

The role of quorum-sensing systems in a mouse model of chronic Pseudomonas aeruginosa infection was studied. A chronic P. aeruginosa respiratory infection model was established by placement of a tube pre-coated with strain PAO1 (wild-type) or a quorum-sensing mutant, namely PAO-JP1 ({Delta}lasI), PDO100 ({Delta}rhlI) or PAO-JP2 ({Delta}lasI/{Delta}rhlI), in the bronchus. At day 14 after infection, the numbers of viable bacteria in the quorum-sensing-mutant groups were lower than in the wild-type group. Histopathological examination showed milder inflammatory changes in the lungs infected with the mutant groups compared with the wild-type group. In the bronchoalveolar lavage fluid from the quorum-sensing-system-mutant groups the proportion of neutrophils was lower than in wild-type group. These findings indicate that the quorum-sensing system plays an important role in chronic P. aeruginosa respiratory infection.

{dagger}These authors contributed equally to this work.

Abbreviations: BALF, bronchoalveolar lavage fluid; QS, quorum sensing.






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