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J Med Microbiol 54 (2005), 323-326; DOI: 10.1099/jmm.0.45873-0
© 2005 Society for General Microbiology
ISSN 0022-2615

Role of interleukin-18 in experimental infections with Streptococcus pneumoniae

G K Paterson, C E Blue{dagger} and T J Mitchell

Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK

Correspondence T. J. Mitchell t.mitchell{at}bio.gla.ac.uk

Received August 20, 2004
Accepted December 16, 2004

IL-18, a multifunctional cytokine, has been shown to be involved in the immune response to numerous pathogens including several bacterial species. To study its role in infection by the Gram-positive bacterium Streptococcus pneumoniae, wild-type and IL-18 knockout BALB/c mice were compared in murine models of pneumococcal pneumonia, bacteraemia and nasopharyngeal colonization. The influence of IL-18 varied with the infection type, whereby it contributed to increased bacterial loads in pneumonia, reduced levels of colonization and had no effect on levels of bacteraemia following intravenous challenge. Likewise, the influence of IL-18 on pneumonia varied between two infecting pneumococcal strains. Comparison of these results with previous data also suggested that the influence of IL-18 in pneumococcal pneumonia differs with the mouse strain genetic background. Overall, these results demonstrate the complex influence of IL-18 in the response to the pneumococcus.

{dagger}Present address: Division of Virology, University of Glasgow, Glasgow G11 5JR, UK.

Abbreviations: BALF, bronchoalveloar lavage fluid; IFN, interferon; IL, interleukin.




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