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J Med Microbiol 54 (2005), 269-271; DOI: 10.1099/jmm.0.45635-0
© 2005 Society for General Microbiology
ISSN 0022-2615

Drug-sensitivity profile of clinical Mycobacterium tuberculosis isolates – a retrospective study from a chest-disease institute in India

T Dam{dagger}{ddagger}, M Isa{dagger} and M Bose

Department of Microbiology, VP Chest Institute, University of Delhi, Delhi 110 007, India

Correspondence M. Bose mridulabose{at}hotmail.com

Received February 15, 2004
Accepted October 25, 2004

Multi-drug-resistant tuberculosis (MDR-TB) is a major public-health problem, because treatment is complicated and patients remain infectious for months or years, despite receiving the best available therapy. To gain better understanding of MDR-TB, a retrospective study was initiated to determine the level of drug resistance among patients in a chest-disease institute in India. Two hundred and sixty-three isolates from treatment-failure pulmonary tuberculosis patients (20–70 years) were studied. Drug-sensitivity testing was performed by the modified-proportion method. First- and second-line drugs, along with two quinolone drugs (ofloxacin and ciprofloxacin), were tested. Patients included in this study did not improve with therapy; however, 151 isolates (57.5 %) were susceptible to all four first-line antituberculosis drugs. This study reports low resistance to fluoroquinolones among the strains present in these patients.

{dagger}These authors contributed equally to this work.

{ddagger}Present address: Room 204, Mudd Hall, 3400 N Charles Street, Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.

Abbreviations: AFB, acid-fast bacilli; EMB, ethambutol; INH, isoniazid; MDR-TB, multi-drug-resistant tuberculosis; RIF, rifampicin, SM, streptomycin.






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