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J Med Microbiol 54 (2005), 143-147; DOI: 10.1099/jmm.0.45799-0
© 2005 Society for General Microbiology
ISSN 0022-2615

Detection of binary-toxin genes (cdtA and cdtB) among Clostridium difficile strains isolated from patients with C. difficile-associated diarrhoea (CDAD) in Poland

Hanna Pituch1, Maja Rupnik2, Piotr Obuch-Woszczatynski1, Ana Grubesic2, Felicja Meisel-Mikolajczyk1 and Miroslaw Luczak1

1Department of Medical Microbiology, Medical University of Warsaw, 5 Chalubinski Street, 02-004 Warsaw, Poland 2Department of Biology, University of Ljubljana, Ljubljana, Slovenia

Correspondence Hanna Pituch hanna.pituch{at}ib.amwaw.edu.pl

Received June 28, 2004
Accepted August 25, 2004

Clostridium difficile A+B+ and A–B+ strains isolated from stool samples of patients with C. difficile-associated diarrhoea (CDAD) were selected from the University Hospital Warsaw collection. The binary-toxin genes cdtA and cdtB were detected by PCR in five of the 41 A+B+ strains tested, but in none of the 17 A–B+ strains tested, giving 8.6 % prevalence (5/58) of binary-toxin-positive strains. All of the strains that were positive for binary-toxin genes were grouped into toxinotype IV, suggesting that in this institution toxinotype IV might dominate among the population of C. difficile with binary-toxin genes.

Abbreviations: AAD, antibiotic-associated diarrhoea; AAC, antibiotic-associated colitis; CDAD, C. difficile-associated diarrhoea; PaLoc, pathogenicity locus; PMC, pseudomembranous colitis.




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