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J Med Microbiol 54 (2005), 113-117; DOI: 10.1099/jmm.0.45810-0
© 2005 Society for General Microbiology
ISSN 0022-2615

Revised nomenclature of Clostridium difficile toxins and associated genes

Maja Rupnik1, Bruno Dupuy2, Neil F Fairweather3, Dale N Gerding4,5, Stuart Johnson4,5, Ingo Just6, David M Lyerly7, Michel R Popoff8, Julian I Rood9, Abraham L Sonenshein10, Monica Thelestam11, Brendan W Wren12, Tracy D Wilkins7 and Christoph von Eichel-Streiber13

1University of Ljubljana, Department of Biology, Vecna pot 111, 1000 Ljubljana, Slovenia 2,8Unité de Génétique Moléculaire Bactérienne2 and Unité des Toxines Microbiennes8, Institut Pasteur, Paris, France 3Centre for Molecular Microbiology and Infection, Imperial College, London, UK 4Hines VA Hospital, Hospital/151 Fifth Avenue & Roosevelt Road, Hines, IL 60141, USA 5Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA 6Institute of Toxicology, Hannover Medical School, Hannover, Germany 7TechLab Inc., Blacksburg, VA, USA 9Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Victoria 3800, Australia 10Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA 11Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden 12London School of Hygiene and Tropical Medicine, University of London, UK 13Institute of Medical Microbiology and Hygiene, Johannes Gutenberg University of Mainz, D-55101 Mainz, Germany

Correspondence Maja Rupnik maja.rupnik{at}bf.uni-lj.si

Received July 3, 2004
Accepted August 6, 2004

Several different nomenclatures have been applied to the Clostridium difficile toxins and their associated genes. This paper summarizes the new nomenclature that has been agreed to by the research groups currently active in the field. The revised nomenclature includes C. difficile toxins and other related large clostridial toxins produced by Clostridium sordellii and Clostridium novyi, and corresponding toxin genes, as well as toxin production types of C. difficile strains.

This paper was presented at the round-table discussion on Clostridium difficile nomenclature at the First International Clostridium difficile Symposium, Kranjska Gora, Slovenia, 5–7 May 2004.

Abbreviation: LCT, large clostridial toxin.




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