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J Med Microbiol 54 (2005), 1239-1242; DOI: 10.1099/jmm.0.46189-0
© 2005 Society for General Microbiology
ISSN 0022-2615

Investigations into the influence of host genetics on the predominant eubacteria in the faecal microflora of children

Jessica A Stewart1, Vinton S Chadwick1 and Alan Murray2

1Wakefield Gastroenterology Research Institute, Wakefield Hospital, Private Bag 7909, Wellington South, New Zealand 2Institute of Veterinary, Animal & Biomedical Sciences, Massey University, Palmerston North, New Zealand

Correspondence Jessica A. Stewart jess-stewart{at}paradise.net.nz

Received 5 June 2005
Accepted 16 August 2005

The eubacterial population was studied in faecal samples of related and unrelated children. Temporal temperature gradient gel electrophoresis (TTGE) provided a snapshot of the bacterial population and allowed calculation of the degree of similarity in the predominant faecal microflora of identical twin pairs, fraternal twin pairs and unrelated paired controls. The highest levels of similarity were found in genetically identical twins. Significant differences were observed between the identical and fraternal twins (P = 0.037), strongly suggesting a genetic influence over the composition of the faecal microflora. The unrelated control group had the lowest similarity and was significantly different from the twins (P = 0.001). The results of this study indicate that host genetics influence the composition of the dominant eubacterial population in children.

Abbreviation: TTGE, temporal temperature gradient gel electrophoresis




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