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J Med Microbiol 54 (2005), 1107-1110; DOI: 10.1099/jmm.0.46084-0
© 2005 Society for General Microbiology
ISSN 0022-2615

Disseminated Nocardia farcinica infection in a uraemia patient with idiopathic thrombocytopenia purpura receiving steroid therapy

Chih-Cheng Lai1, Li-Na Lee1,2, Lee-Jene Teng3, Ming Shiou Wu1, Jui-Chang Tsai4 and Po-Ren Hsueh1,2

1,2Department of Internal Medicine1 and Department of Laboratory Medicine2, National University Hospital, Taipei, Taiwan 3,4School of Medical Technology3 and Center for Optoelectronic Biomedicine4, National Taiwan University College of Medicine, Taipei, Taiwan

Correspondence Po-Ren Hsueh hsporen{at}ha.mc.ntu.edu.tw

Received March 10, 2005
Accepted July 13, 2005

Nocardia farcinica has been reported as an increasingly frequent cause of localized and disseminated infections in immunocompromised patients in recent years, but N. farcinica bacteraemia remains a rare finding. Here, the case is described of a 68-year-old man with end-stage renal disease and idiopathic thrombocytopenia purpura treated with steroid therapy who developed disseminated infection (bacteraemia, multilobar pneumonia and brain abscesses) due to N. farcinica. The isolate was confirmed by partial sequencing analysis of the 16S rRNA gene. The patient recovered after prolonged trimethoprim-sulfamethoxazole therapy with no recurrence in over 1 year.

Abbreviation: ITP, idiopathic thrombocytopenia purpura.






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