J Med Microbiol NEW Faster Access
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alem, M. A.
Right arrow Articles by Douglas, L J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alem, M. A.
Right arrow Articles by Douglas, L J.
Agricola
Right arrow Articles by Alem, M. A.
Right arrow Articles by Douglas, L J.
J Med Microbiol 54 (2005), 1001-1005; DOI: 10.1099/jmm.0.46172-0
© 2005 Society for General Microbiology
ISSN 0022-2615

Prostaglandin production during growth of Candida albicans biofilms

Mohammed AS Alem and L Julia Douglas

Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK

Correspondence L. Julia Douglas J.Douglas{at}bio.gla.ac.uk

Received May 25, 2005
Accepted July 12, 2005

Both biofilms and planktonic (suspended) cells of Candida albicans synthesized extracellular prostaglandin(s) during growth at 37 °C, but biofilm cells secreted significantly more prostaglandin(s) when production was determined on the basis of cell dry weight. Prostaglandin synthesis by both cell types was sensitive to the cyclooxygenase inhibitors aspirin, diclofenac and etodolac. A morphological mutant blocked in two signalling pathways (cph1/cph1 efg1/efg1) produced prostaglandin levels similar to those of the parent strain, but formed yeast-only biofilms. These results suggest that prostaglandin production could be a significant virulence factor in biofilm-associated infections, although its role in C. albicans morphogenesis remains unclear.

Abbreviation: COX, cyclooxygenase.




This article has been cited by other articles:


Home page
 J Med MicrobiolHome page
M. Venkatesh, L. Rong, I. Raad, and J. Versalovic
Novel synergistic antibiofilm combinations for salvage of infected catheters
J. Med. Microbiol., July 1, 2009; 58(7): 936 - 944.
[Abstract] [Full Text] [PDF]

Home page
 J Med MicrobiolHome page
K. A. Toenjes, B. C. Stark, K. M. Brooks, and D. I. Johnson
Inhibitors of cellular signalling are cytotoxic or block the budded-to-hyphal transition in the pathogenic yeast Candida albicans
J. Med. Microbiol., June 1, 2009; 58(6): 779 - 790.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
M. Martins, M. Henriques, J. Azeredo, S. M. Rocha, M. A. Coimbra, and R. Oliveira
Morphogenesis Control in Candida albicans and Candida dubliniensis through Signaling Molecules Produced by Planktonic and Biofilm Cells
Eukaryot. Cell, December 1, 2007; 6(12): 2429 - 2436.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. R. Erb-Downward and M. C. Noverr
Characterization of Prostaglandin E2 Production by Candida albicans
Infect. Immun., July 1, 2007; 75(7): 3498 - 3505.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
M. A. S. Alem, M. D. Y. Oteef, T. H. Flowers, and L. J. Douglas
Production of Tyrosol by Candida albicans Biofilms and Its Role in Quorum Sensing and Biofilm Development
Eukaryot. Cell, October 1, 2006; 5(10): 1770 - 1779.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2005 Society for General Microbiology.