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J Med Microbiol 54 (2005), 93-96; DOI: 10.1099/jmm.0.45845-0
© 2005 Society for General Microbiology
ISSN 0022-2615

Molecular detection of Treponema denticola and Porphyromonas gingivalis in carotid and aortic atheromatous plaques by FISH: report of two cases

Francesca Cavrini1,5, Vittorio Sambri1, Annette Moter2, Dora Servidio3, Antonella Marangoni1, Lucio Montebugnoli3, Federico Foschi1,3, Carlo Prati3, Roberto Di Bartolomeo4 and Roberto Cevenini1

1Section of Microbiology, DMCSS, University of Bologna, Bologna, Italy 2Institut für Mikrobiologie und Hygiene, Charitè Universitätsmedizin, Berlin, Germany 3Department of Oral Sciences, University of Bologna, Bologna, Italy 4Department of Surgical Sciences, Anaesthesiology and Transplants, University of Bologna, Bologna, Italy 5Centro Regionale di Riferimento per le Emergenze Microbiologiche, Bologna, Italy

Correspondence Vittorio Sambri vsambri{at}med.unibo.it

Received July 29, 2004
Accepted October 1, 2004

Treponema denticola and Porphyromonas gingivalis have been identified in atheromatous plaques of two patients suffering from atherosclerosis by PCR and fluorescence in situ hybridization (FISH). The use of the FISH technique suggested that these periodontopathic micro-organisms might be metabolically active within the wall of arteries, under the atherosclerotic lesion.

Abbreviations: CABG, coronary artery by-pass grafting; FISH, fluorescence in situ hybridization; PTCA, percutaneous transluminal coronary angioplasty.




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