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J Med Microbiol 54 (2005), 7-13; DOI: 10.1099/jmm.0.45736-0
© 2005 Society for General Microbiology
ISSN 0022-2615

Compensatory response of IL-1 gene knockout mice after pulmonary infection with Klebsiella pneumoniae

Masaaki Tanabe1, Tetsuya Matsumoto1, Kazutoshi Shibuya2, Kazuhiro Tateda1, Shuichi Miyazaki1, Akio Nakane3, Yoichiro Iwakura4 and Keizo Yamaguchi1

1,2Department of Microbiology1 and Department of Pathology2, Omori Hospital, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku Tokyo, Japan 3Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki, Japan 4Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Correspondence Tetsuya Matsumoto tetsu{at}med.toho-u.ac.jp

Received May 7, 2004
Accepted September 21, 2004

This study was designed to determine the role of interleukin (IL)-1 in the inflammatory response against experimentally induced pneumonia caused by Klebsiella pneumoniae. The host immune responses of IL-1 gene knockout (IL-1 KO) mice and immunocompetent wild-type (WT) mice were compared after pulmonary infection with K. pneumoniae. There were no significant differences between the survival rates and viable bacterial counts in lungs and blood of IL-1 KO and WT mice after pulmonary infections under different conditions. Histopathological analysis showed a similar inflammatory response in both groups of mice. However, in the early stage of infection, the level of tumour necrosis factor alpha (TNF-{alpha}) in homogenized lungs of IL-1 KO mice was significantly higher than in WT mice. To determine the role of endogenous TNF-{alpha} in the recovery of the defence mechanism in IL-1 KO mice, mice were treated with an anti-TNF-{alpha} mAb before infection with K. pneumoniae. The results revealed a significantly lower survival rate of anti-TNF-{alpha} mAb-treated IL-1 KO mice than BSA-treated IL-1 KO mice. The data suggest that compensatory production of TNF-{alpha} in IL-1 KO mice contributes to the host defence against K. pneumoniae infection.

Abbreviations: BALF, bronchoalveolar lavage fluid; KO, knockout; WT, wild-type.




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