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Genetic diversity of the dnaJ gene in the Mycobacterium avium complex

Yukio Morita¹, Soichi Maruyama², Hidenori Kabeya², Akira Nagai¹, Kunihisa Kozawa¹, Masahiko Kato^3, , Takashi Nakajima⁴, Takeshi Mikami², Yasuji Katsube² and Hirokazu Kimura¹

¹Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, Japan ²Laboratory of Veterinary Public Health, Department of Veterinary Medicine, College of Bioresource Science, Nihon University, Fujisawa, Kanagawa, Japan ³Department of Pediatrics, Gunma University, School of Medicine, Maebashi, Gunma, Japan ⁴Laboratory of Food Microbiology and Hygiene, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan

Correspondence Yukio Morita morita-yu{at}pref.gunma.jp

Received January 19, 2004
Accepted March 12, 2004

The Mycobacterium avium complex (MAC) is associated with various diseases in humans as a zoonosis. The dnaJ gene was partially sequenced in Schaefer's 28 reference strains of MAC, 14 human MAC isolates and 22 veterinary isolates. From substitutions affecting 21–32 nucleotides, all strains could be classified into 14 groups. Most nucleotide substitutions did not alter amino acid sequences. Approximately 8 % genetic diversity was seen in these strains, which divided into two clusters: cluster I (0.8 % genetic diversity), comprising the reference strain serotypes 1–6, 8–11 and 21 and all isolates; and cluster II (7 % genetic diversity), comprising the remaining reference strains. Analysis of the dnaJ gene in MAC may be useful in epidemiological studies.

Present address:

Abbreviation: MAC, Mycobacterium avium complex.

The GenBank/EMBL/DDBJ accession numbers for the dnaJ sequences of the M. avium complex strains are AB097876–B097880, AB097882–AB097903 and AB109222.

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