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J Med Microbiol 53 (2004), 735-740; DOI: 10.1099/jmm.0.45598-0
© 2004 Society for General Microbiology
ISSN 0022-2615

Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via Toll-like receptor 2

Clett Erridge1, Alison Pridmore2, Adrian Eley2, John Stewart1 and Ian R. Poxton1

1Medical Microbiology, Centre for Infectious Diseases, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK 2Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK

Correspondence Ian R. Poxton I.R.Poxton{at}ed.ac.uk

Received January 15, 2004
Accepted March 17, 2004

Recognition of bacterial lipopolysaccharide (LPS) is critical in the host defence against Gram-negative infection. While enterobacterial LPS signals via Toll-like receptor 4 (TLR4), it has recently been reported that the LPS of Leptospira interrogans, Legionella pneumophila, Rhizobium species Sin-1 and at least one strain of Porphyromonas gingivalis are capable of signalling via TLR2. Using a TLR transfection assay and measurement of an NF-{kappa}B-sensitive promoter region, the results show that the LPS of Bacteroides fragilis NCTC-9343, Chlamydia trachomatis LGV-1 and Pseudomonas aeruginosa PAC-611 also signal via TLR2 and it is pointed out that all TLR2-signalling LPS discovered to date demonstrate relatively weak endotoxicity in some models and structural features distinct from those LPS shown to signal via TLR4.

Abbreviations: LPS, lipopolysaccharide; TLR, Toll-like receptor.




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