J Med Microbiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holden, N. J.
Right arrow Articles by Gally, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holden, N. J.
Right arrow Articles by Gally, D. L.
Agricola
Right arrow Articles by Holden, N. J.
Right arrow Articles by Gally, D. L.
J Med Microbiol 53 (2004), 585-593; DOI: 10.1099/jmm.0.05491-0
© 2004 Society for General Microbiology
ISSN 0022-2615

Switches, cross-talk and memory in Escherichia coli adherence

Nicola J. Holden and David L. Gally

Zoonotic and Animal Pathogens Research Laboratory, Medical Microbiology, Teviot Place, University of Edinburgh, Edinburgh, EH8 9AG, UK

Correspondence David L. Gally d.gally{at}ed.ac.uk


Escherichia coli is a successful commensal and pathogen. Its pathogenic diversity stems from the acquisition and expression of multiple virulence-associated loci. Many of the key virulence factors are surface structures involved in adherence and motility. These are important antigens and their expression is limited by phase-variable genetic switches that are considered to act randomly. This review considers the possibility that such stochastic expression within a bacterial population belies sequential or co-ordinate control at the level of the individual bacterium. Co-ordinated expression or cross-talk between virulence loci can lead to a programmed set of events within a bacterium analogous to a simple form of electronic memory that is of benefit during infection.




This article has been cited by other articles:


Home page
 J. Bacteriol.Home page
L. U. Magnusson, B. Gummesson, P. Joksimovic, A. Farewell, and T. Nystrom
Identical, Independent, and Opposing Roles of ppGpp and DksA in Escherichia coli
J. Bacteriol., July 15, 2007; 189(14): 5193 - 5202.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
G. C. Ulett, A. N. Mabbett, K. C. Fung, R. I. Webb, and M. A. Schembri
The role of F9 fimbriae of uropathogenic Escherichia coli in biofilm formation
Microbiology, July 1, 2007; 153(7): 2321 - 2331.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. Holden, M. Totsika, L. Dixon, K. Catherwood, and D. L. Gally
Regulation of P-Fimbrial Phase Variation Frequencies in Escherichia coli CFT073
Infect. Immun., July 1, 2007; 75(7): 3325 - 3334.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Y. Xie, Y. Yao, V. Kolisnychenko, C.-H. Teng, and K. S. Kim
HbiF Regulates Type 1 Fimbriation Independently of FimB and FimE
Infect. Immun., July 1, 2006; 74(7): 4039 - 4047.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. S. Low, F. Dziva, A. G. Torres, J. L. Martinez, T. Rosser, S. Naylor, K. Spears, N. Holden, A. Mahajan, J. Findlay, et al.
Cloning, Expression, and Characterization of Fimbrial Operon F9 from Enterohemorrhagic Escherichia coli O157:H7
Infect. Immun., April 1, 2006; 74(4): 2233 - 2244.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
N. J. Holden, M. Totsika, E. Mahler, A. J. Roe, K. Catherwood, K. Lindner, U. Dobrindt, and D. L. Gally
Demonstration of regulatory cross-talk between P fimbriae and type 1 fimbriae in uropathogenic Escherichia coli.
Microbiology, April 1, 2006; 152(Pt 4): 1143 - 1153.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2004 Society for General Microbiology.