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J Med Microbiol 53 (2004), 501-504; DOI: 10.1099/jmm.0.05352-0
© 2004 Society for General Microbiology
ISSN 0022-2615

Transfer of specific antibodies results in increased expression of TNF-{alpha} and IL12 and recruitment of neutrophils to the site of a cutaneous Francisella tularensis infection

Stephan Stenmark1 and Anders Sjöstedt2

Departments of Clinical Microbiology, Infectious Diseases1 and Clinical Bacteriology2, Umeå University, Umeå, Sweden

Correspondence Anders Sjöstedt anders.sjostedt{at}climi.umu.se

Received June 19, 2003
Accepted February 2, 2004

This study demonstrates that passive transfer of Francisella tularensis-specific antibodies before experimental cutaneous infection with the live vaccine strain of F. tularensis has profound effects. Recipient mice showed stronger staining for TNF-{alpha} and IL12, and larger numbers of neutrophils in skin samples after infection than control mice.




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