HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chen, W. Articles by Wang, J. Search for Related Content PubMed PubMed Citation Articles by Chen, W. Articles by Wang, J. Agricola Articles by Chen, W. Articles by Wang, J.

Antibody response and viraemia during the course of severe acute respiratory syndrome (SARS)-associated coronavirus infection

Weijun Chen^1,2, Zuyuan Xu^1,3, Jingsong Mu⁴, Ling Yang^1,2, Haixue Gan², Feng Mu^1,2, Baoxing Fan⁵, Bo He², Shengyong Huang², Bo You², Yongkui Yang², Xiangjun Tang², Ling Qiu⁶, Yan Qiu⁷, Jie Wen^1,2, Jianqiu Fang^1,2 and Jian Wang^1,2

¹Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China ²Beijing BGI-GBI Biotech Co. Ltd, Beijing 101300, China ³Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China ⁴Beijing 302 Hospital, Beijing 100039, China ⁵Beijing 301 Hospital, Beijing 100853, China ⁶Beijing Union Hospital, Beijing 100730, China ⁷Beijing Red Cross Blood Center, Beijing 100088, China

Correspondence Weijun Chen chenweijun72{at}sohu.com, Jian Wang wangjian{at}genomics.org.cn

Received December 18, 2003
Accepted January 8, 2004

To understand the time-course of viraemia and antibody responses to severe acute respiratory syndrome-associated coronavirus (SARS-CoV), RT-PCR and ELISA were used to assay 376 blood samples from 135 SARS patients at various stages of the illness, including samples from patients who were in their early convalescent phase. The results showed that IgM antibodies decreased and became undetectable 11 weeks into the recovery phase. IgG antibodies, however, remained detectable for a period beyond 11 weeks and were found in 100 % of patients in the early convalescent phase. SARS-CoV viraemia mainly appeared 1 week after the onset of illness and then decreased over a period of 1 month, becoming undetectable in the blood samples of the convalescent patients. At the peak of viraemia, viral RNA was detectable in 75 % of blood samples from patients who were clinically diagnosed with SARS 1 or 2 weeks before the test.

Abbreviation: SARS-CoV, severe acute respiratory syndrome-associated coronavirus.

This article has been cited by other articles:

				M. D. SORENSEN, B. SORENSEN, R. GONZALEZ-DOSAL, C. J. MELCHJORSEN, J. WEIBEL, J. WANG, C. W. JUN, Y. HUANMING, and P. KRISTENSEN Severe Acute Respiratory Syndrome (SARS): Development of Diagnostics and Antivirals. Ann. N.Y. Acad. Sci., May 1, 2006; 1067: 500 - 505. [Abstract] [Full Text] [PDF]

				L. Xie, Y. Liu, Y. Xiao, Q. Tian, B. Fan, H. Zhao, and W. Chen Follow-up Study on Pulmonary Function and Lung Radiographic Changes in Rehabilitating Severe Acute Respiratory Syndrome Patients After Discharge Chest, June 1, 2005; 127(6): 2119 - 2124. [Abstract] [Full Text] [PDF]