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J Med Microbiol 53 (2004), 287-291; DOI: 10.1099/jmm.0.05407-0
© 2004 Society for General Microbiology
ISSN 0022-2615

Decreased susceptibility to tiamulin and valnemulin among Czech isolates of Brachyspira hyodysenteriae

Dana Lobová, Jiri Smola and Alois Cizek

Institute of Microbiology and Immunology, Section of Pathobiology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Palackého 1-3, 612 42 Brno, Czech Republic

Correspondence Alois Cizek cizeka{at}vfu.cz

Received July 30, 2003
Accepted January 15, 2004

The agar dilution method was used to investigate the sensitivity to pleuromutilins of 100 isolates of Brachyspira hyodysenteriae isolated from 63 pig farms between 1997 and 2001. In the period under investigation, MICs to both tiamulin and valnemulin increased, with differences between the periods 1997–98 and 1999–2001 being statistically significant (P < 0.001 for tiamulin and P < 0.0001 for valnemulin). Between 1997 and 2001, the MIC50 and MIC90 of tiamulin increased from 0.062 and 0.25 µg ml-1, respectively, to 1.0 and 4.0 µg ml-1. Valnemulin MIC50 and MIC90 were <= 0.031 µg ml-1 in 1997 and by 2001 were respectively, 2.0 and 8.0 µg ml-1. The increase in MICs of tiamulin and valnemulin demonstrated in this study reflect the intensity of pleuromutilin use in the treatment of swine dysentery in the Czech Republic.

This paper was presented at the Second International Conference on Colonic Spirochaetal Infections in Animals and Humans, Edinburgh, UK, 2–4 April 2003.

Abbreviations: SD, swine dysentery; TSBA, trypticase soy agar with 5 % ovine blood; WCABA, Wilkins–Chalgren anaerobe agar with 5 % ovine blood.




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