HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Karlsson, M. Articles by Franklin, A. Search for Related Content PubMed PubMed Citation Articles by Karlsson, M. Articles by Franklin, A. Agricola Articles by Karlsson, M. Articles by Franklin, A.

Further characterization of porcine Brachyspira hyodysenteriae isolates with decreased susceptibility to tiamulin

Department of Antibiotics¹ and Department of Bacteriology², National Veterinary Institute, SE-751 89 Uppsala, Sweden

Correspondence M. Karlsson marit.karlsson{at}sva.se

Received July 22, 2003
Accepted September 8, 2003

Brachyspira hyodysenteriae is the causative agent of swine dysentery, a severe diarrhoeal disease in pigs. Few drugs are available to treat the disease, owing to both antimicrobial resistance and withdrawal of drugs authorized for use in pigs. Tiamulin is the drug of choice in many countries, but isolates with decreased susceptibility have recently been reported. The mechanism of tiamulin resistance in B. hyodysenteriae is not known and this facet is essential to understand the dissemination of the trait. To study the resistance epidemiology of B. hyodysenteriae, further characterization of a set of isolates from Germany (n = 16) and the UK (n = 6) with decreased susceptibility to tiamulin was performed. The relatedness between the isolates was studied by comparing PFGE patterns, and the in vitro susceptibility to five other antimicrobials (aivlosin, doxycycline, salinomycin, chloramphenicol and avilamycin) was also determined. For comparison of the antimicrobial-susceptibility pattern, Swedish (n = 20) and British (n = 4) tiamulin-susceptible isolates were tested. The German isolates represented several different PFGE patterns, indicating that tiamulin usage has been sufficient to select clones with decreased tiamulin susceptibility at different farms in Germany. The PFGE pattern for the six British isolates with decreased tiamulin susceptibility was identical to that of the German isolates, and they had a similar antimicrobial-susceptibility pattern, except for resistance to aivlosin, which was only found in a few German isolates. No other co-resistance with tiamulin was found.

This article has been cited by other articles:

				T. Rasback, K.-E. Johansson, D. S. Jansson, C. Fellstrom, M. Y. Alikhani, T. La, D. S. Dunn, and D. J. Hampson Development of a multilocus sequence typing scheme for intestinal spirochaetes within the genus Brachyspira Microbiology, December 1, 2007; 153(12): 4074 - 4087. [Abstract] [Full Text] [PDF]

				K. S. Long, L. H. Hansen, L. Jakobsen, and B. Vester Interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center. Antimicrob. Agents Chemother., April 1, 2006; 50(4): 1458 - 1462. [Abstract] [Full Text] [PDF]