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J Med Microbiol 53 (2004), 273-280; DOI: 10.1099/jmm.0.05323-0
© 2004 Society for General Microbiology
ISSN 0022-2615

Experimental swine dysentery: comparison between infection models

Magdalena Jacobson1, Claes Fellström1, Ronny Lindberg2, Per Wallgren1,3 and Marianne Jensen-Waern1

1,2Department of Large Animal Clinical Sciences1 and Department of Pathology2, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden 3National Veterinary Institute, Uppsala, Sweden

Correspondence Magdalena Jacobson Magdalena.Jacobson{at}kirmed.slu.se

Received May 27, 2003
Accepted December 24, 2003

The aim of the present study was to develop a reproducible porcine infection model with Brachyspira hyodysenteriae. The influence of different factors was evaluated, namely, age, a diet containing large quantities of soybean meal, housing and administration of cortisol or antacids. Furthermore, the synergistic effect of additional bacteria (Escherichia coli O141, Bacteroides vulgatus or a mixture of Bacteroides fragilis, a field isolate of Bacteroides and Fusobacterium necrophorum) was studied. Experimental infection resulted in an increase in the serum concentrations of the acute-phase proteins serum amyloid A and haptoglobin and the percentages of neutrophils and monocytes. These alterations were specifically related to haemorrhagic diarrhoea. Inoculation combined with feeding of large quantities of soybean meal and group-housing induced swine dysentery in all experimental animals. If the pigs were fed soybean meal, kept in single pens and circulated between the pens, five out of nine developed disease.

This paper was presented at the Second International Conference on Colonic Spirochaetal Infections in Animals and Humans, Edinburgh, UK, 2–4 April 2003.

Abbreviations: APP, acute-phase protein; MACs, microflora-associated characteristics; SAA, serum amyloid A; VFA, volatile fatty acids.




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R. Jonasson, M. Andersson, T. Rasback, A. Johannisson, and M. Jensen-Waern
Immunological alterations during the clinical and recovery phases of experimental swine dysentery.
J. Med. Microbiol., July 1, 2006; 55(Pt 7): 845 - 855.
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