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J Med Microbiol 53 (2004), 103-106; DOI: 10.1099/jmm.0.05297-0
© 2004 Society for General Microbiology
ISSN 0022-2615

Lack of circulating Candida mannoprotein antigen in patients with focal hepatosplenic candidiasis

Corrado Girmenia1, Pietro Martino1, Flavia De Bernardis2, Maria Boccanera2 and Antonio Cassone2

1Dipartimento di Biotecnologie Cellulari ed Ematologia, University ‘La Sapienza', Via Benevento 6, 00161 Rome, Italy 2Dipartimento di Batteriologia e Micologia Medica, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy

Correspondence Corrado Girmenia girmenia{at}bce.uniroma1.it

Received April 28, 2003
Accepted November 6, 2003

The significance of Candida mannoprotein serum detection in 15 patients with haematological malignancies and proven (six cases) or probable (nine cases) hepatosplenic candidiasis was retrospectively evaluated. Circulating mannoprotein antigen was detected in three of six and in one of two serum samples from two patients with probable infection. The antigen was not detected in 38 serum samples of 13 (87 %) patients. Thus, in contrast to other deep-seated Candida infections, mannoprotein is infrequently detectable during focal hepatosplenic candidiasis and does not appear to be of diagnostic value.

Abbreviation: MP, mannoprotein.






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