HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bruun, B. Articles by Kilian, M. Search for Related Content PubMed PubMed Citation Articles by Bruun, B. Articles by Kilian, M. Agricola Articles by Bruun, B. Articles by Kilian, M.

Clonal relationship of recent invasive Haemophilus influenzae serotype f isolates from Denmark and the United States

¹Department of Clinical Microbiology, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark ²Department of Clinical Microbiology, Hillerød Hospital, Helsevej 2, DK 3400 Hillerød, Denmark ³Department of Clinical Microbiology, Odense University Hospital, J. B. Winsløvsvej 21.2, DK 5000 Odense C, Denmark ⁴Department of Clinical Microbiology, Hvidovre Hospital, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark ⁵Department of Medical Microbiology and Immunology, Århus University, Universitetsparken, DK 8000 Århus C, Denmark

Correspondence Bente Gahrn-Hansen b.gahrn-hansen{at}ouh.fyns-amt.dk

Received May 18, 2004
Accepted July 29, 2004

Surveillance performed after the introduction of general Haemophilus influenzae serotype b (Hib) vaccination in Denmark identified 13 cases of invasive bacteraemic H. influenzae serotype f (Hif) disease in adults over a period of 7 years. Bacteraemic respiratory tract infections accounted for 61 % of cases, but meningitis, epiglottitis and osteoarthritis were also seen. Recent Danish isolates were compared to recent American isolates, historical Hif strains and non-Hif invasive strains. Results of conventional serotyping were confirmed by PCR detection of the serotype-f-specific cap and bexA gene sequences. Multilocus enzyme electrophoresis typing revealed that recent Danish and American isolates belonged to a single Hif clone, which may be undergoing expansion. The need for accurate serotyping of H. influenzae to enable reliable monitoring for Hib replacement by other capsular types is emphasized.

This article has been cited by other articles:

				N. Norskov-Lauritsen Detection of Cryptic Genospecies Misidentified as Haemophilus influenzae in Routine Clinical Samples by Assessment of Marker Genes fucK, hap, and sodC J. Clin. Microbiol., August 1, 2009; 47(8): 2590 - 2592. [Abstract] [Full Text] [PDF]

				E. McLellan, K. Suvarna, and R. Townsend Fatal necrotizing fasciitis caused by Haemophilus influenzae serotype f J. Med. Microbiol., February 1, 2008; 57(2): 249 - 251. [Abstract] [Full Text] [PDF]

				M. Samuelsson, T. Hallstrom, A. Forsgren, and K. Riesbeck Characterization of the IgD Binding Site of Encapsulated Haemophilus influenzae Serotype b J. Immunol., May 15, 2007; 178(10): 6316 - 6319. [Abstract] [Full Text] [PDF]