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Identification of a novel antigen of pathogenic Leptospira spp. that reacted with convalescent mice sera

Department of Bacteriology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan

Correspondence Haruo Watanabe haruwata{at}nih.go.jp

Received December 10, 2002
Accepted March 28, 2003

The virulence of leptospires isolated from human patients against C3H/HeJ mice was investigated. Infection with clinical isolates from patients with severe leptospirosis was lethal to C3H/HeJ mice, suggesting that C3H/HeJ mice are suitable as an acute lethal model of severe leptospirosis. Using this model, a novel antigen of pathogenic Leptospira spp. (named LAg42), which reacted with convalescent mice sera, was identified. LAg42 is a 42 kDa inner-membrane protein and its immunogenic region is located in the C-terminal region. The gene for LAg42 is conserved among pathogenic leptospires but not among non-pathogenic leptospires, which suggests its involvement in virulence.

The GenBank/EMBL/DDBJ accession number for the nucleotide sequence of the lag42 gene from L. interrogans serovar manilae strain UP-MMC is AB091092.

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