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Biosynthesis of chondroitinase and hyaluronidase by different strains of Paracoccidioides brasiliensis

¹Instituto Adolfo Lutz, São Paulo, SP, Brazil ²Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, SP, Brazil ³Faculdade de Odontologia, Universidade Estadual de São Paulo, São José dos Campos, SP, Brazil#dReceived 3 April 2002 Accepted 5 February 2003

Correspondence: C. R. Paula (crpmieol{at}uom.com.br)

The biosynthesis of chondroitinase and hyaluronidase by different isolates of Paracoccidioides brasiliensis was investigated in 20 strains isolated from patients (17 strains), a penguin (Pygocelis adeliae, one strain), an armadillo (Dasypus novemcinctus, one strain) and the environment (dog food, one strain). All the P. brasiliensis isolates studied had the ability to produce chondroitinase and hyaluronidase, although differences in colony morphology and enzyme production were detected among them. These results suggest that further investigations should be carried out in the clinical field in order to clarify the potential role of P. brasiliensis enzyme production in the pathogenesis of paracoccidioidomycosis.