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J Med Microbiol 52 (2003), 421-425; DOI: 10.1099/jmm.0.04966-0
© 2003 Society for General Microbiology
ISSN 0022-2615

Prevalence of extended-spectrum ß-lactamase-producing Gram-negative bacteria in septicaemic neonates in a tertiary care hospital

Amita Jain1, Indranil Roy1, Mahendra K. Gupta1, Mala Kumar2 and S. K. Agarwal1

Departments of Microbiology1 and Paediatrics2, King George's Medical College, Lucknow, UP –226 003, India

Correspondence Amita Jain amita602002{at}yahoo.com

Received May 9, 2002
Accepted January 22, 2003

The present study was undertaken to investigate the high incidence of multiresistant Gram-negative bacilli causing neonatal septicaemia. Samples of neonatal blood from 728 suspected cases were obtained in brain heart infusion broth with sodium polyanethol sulfonate. All Gram-negative rods isolated were subsequently subjected to routine antimicrobial susceptibility testing and tests for extended-spectrum ß-lactamase (ESBL) production, as per NCCLS recommendations. ESBL was detected in 86.6 % of Klebsiella spp., 73.4 % of Enterobacter spp. and 63.6 % of Escherichia coli strains. It was also observed that 74.4–80.9 % of these ESBL producers were resistant to cefotaxime and 47.6–59.5 % were resistant to ceftazidime in routine susceptibility testing. Some ESBL producers (36.3–61.5 %) were found to be susceptible to either or both cephalosporins used in this study. It is concluded that indiscriminate use of third-generation cephalosporins may be responsible for the selection of ESBL-producing multiresistant strains in the neonatal intensive-care unit (NICU).

Abbreviations: ESBL, extended-spectrum ß-lactamase; NICU, neonatal intensive-care unit.




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