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J Med Microbiol 52 (2003), 247-249; DOI: 10.1099/jmm.0.05048-0
© 2003 Society for General Microbiology
ISSN 0022-2615

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effect of antimycotic agents on the activity of aspartyl proteinases secreted by Candida albicans

Martin Schaller1, Nikola Krnjaic1, Markus Niewerth1, Gerald Hamm2, Bernhard Hube3 and Hans C. Korting1

1,2Department of Dermatology and Allergology1 and Department of Periodontology2, University of Munich, Frauenlobstr. 9-11, D-80337 München, Germany 3Robert Koch-Institut, Berlin, Germany

Correspondence Martin Schaller Martin.Schaller{at}lrz.uni- muenchen.de

Received 16 August 2002 Accepted 20 November 2002

The inhibitory effect of human immunodeficiency virus (HIV) proteinase inhibitors amprenavir and saquinavir and antifungal agents terbinafine, ketoconazole, amphotericin B and ciclopiroxolamine on aspartyl proteinases (Saps) secreted by Candida albicans was tested in an in vitro spectophotometric assay. As expected, both HIV proteinase inhibitors showed a significant inhibitory effect on Sap activity, which was comparable to that of the classical aspartyl proteinase inhibitor pepstatin A (P < 0.001). Antifungal drugs such as ketoconazole, terbinafine and amphotericin B had no, or only minor, inhibitory effects on proteolytic activity. In contrast, a significant reduction in Sap activity could be demonstrated during treatment with the antifungal agent ciclopiroxolamine (P < 0.001). These results point to a multiple effect of this antimycotic agent and might explain the reduced adherence of C. albicans to human epithelial cells at subinhibitory doses.




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