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J Med Microbiol 52 (2003), 169-171; DOI: 10.1099/jmm.0.04987-0
© 2003 Society for General Microbiology
ISSN 0022-2615

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antifungal properties of 5-hydroxytryptamine (serotonin) against Candida species in vitro

Cornelia Lass-Flörl1, Dietmar Fuchs2, Maximilian Ledochowski3, Cornelia Speth1, Manfred P. Dierich1 and Reinhard Würzner1

1,2Institute of Hygiene and Social Medicine1 and Medical Chemistry and Biochemistry2, University of Innsbruck, Austria 3Department of Clinical Nutrition, University Hospital of Innsbruck, Austria

Correspondence: Cornelia Lass-Flörl Cornelia.Lass-Floerl{at}uibk.ac.at

Received 25 June 2002 Accepted 24 September 2002

In this study the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of 5-hydroxytryptamine (5 HT, serotonin) against clinical isolates of Candida albicans (n = 11), Candida glabrata (n = 9), Candida tropicalis (n = 10) and Candida parapsilosis (ATCC 22019) using a broth microdilution test were investigated. In addition, it was examined whether delayed regrowth as a post-antifungal effect results following short exposure to 5 HT. 5 HT showed antifungal activity towards all isolates of Candida spp. The isolates yielded comparable MIC and MFC values of 5 HT in the range 0.91–7.34 mM and 1.83–14.68 mM, respectively. A lag in regrowth was dependent on the concentration tested. Treatment for 3 h at concentrations of 5 HT below and equipotent to the MFC resulted in a delayed regrowth of 8–12 h for isolates of Candida spp. In conclusion, these in vitro studies clearly demonstrate antifungal effects of 5 HT. Identifying the mode of action could be of great help in developing and researching new antifungal drugs.






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