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J Med Microbiol 52 (2003), 971-974; DOI: 10.1099/jmm.0.05228-0
© 2003 Society for General Microbiology
ISSN 0022-2615

High levels of hydrolytic enzymes secreted by Candida albicans isolates involved in respiratory infections

Annemarie Borst{dagger} and Ad C. Fluit

Eijkman-Winkler Center for Microbiology, Infectious Diseases and Inflammation, University Medical Center, Utrecht, The Netherlands

Correspondence Annemarie Borst aoz0{at}cdc.gov

Received February 14, 2003
Accepted July 24, 2003

Differences in production of two putative virulence factors of Candida albicans, phospholipase and proteinase, were determined for a large panel of clinical C. albicans isolates (n = 186) obtained from the European SENTRY programme. Seventy-two per cent of isolates produced detectable amounts of phospholipase and 95 % of isolates produced detectable amounts of proteinase. There was no clear correlation between the results of the phospholipase and proteinase assays and the geographical distribution of the isolates. However, isolates that originated from respiratory infections produced significantly higher amounts of phospholipase than isolates obtained from blood, the urinary tract or wounds/skin/soft tissue and also appeared to produce more proteinase. These virulent isolates involved in respiratory infections may originate from the oral cavity. Whether these results are caused by selection for these highly virulent isolates remains to be resolved.

{dagger}Present address: Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Mailstop G-11, 1600 Clifton Road, Atlanta, GA 30333, USA.




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Y H Samaranayake, R S Dassanayake, J A. Jayatilake, B P. Cheung, J Y. Yau, K W. Yeung, and L P Samaranayake
Phospholipase B enzyme expression is not associated with other virulence attributes in Candida albicans isolates from patients with human immunodeficiency virus infection
J. Med. Microbiol., June 1, 2005; 54(6): 583 - 593.
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