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J Med Microbiol 52 (2003), 889-892; DOI: 10.1099/jmm.0.05267-0
© 2003 Society for General Microbiology
ISSN 0022-2615

Diagnostic accuracy of serological kits for Helicobacter pylori infection with the same assay system but different antigens in a Japanese patient population

Yuki Obata1, Shogo Kikuchi1, Hiroto Miwa2, Kiyoko Yagyu1, Yingsong Lin1 and Atsushi Ogihara3

1Department of Public Health, Aichi Medical University, School of Medicine, 21, Karimata, Yazako, Nagakute-cho, Aichi-Gun, Aichi 480-1195, Japan 2Department of Gastroenterology, Juntendo University, School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan 3Faculty of Science and Technology, Tokyo University of Science, Yamaguchi, 1-1-1, Daigakudori, Onoda, Yamaguchi 756-0884, Japan

Correspondence Shogo Kikuchi kikuchis{at}aichi-med-u.ac.jp

Received March 28, 2003
Accepted July 7, 2003

Helicobacter pylori infection is thought to be a causal risk factor for gastric carcinoma. Recently, diagnostic accuracy of serological kits for H. pylori infection that were made in Western countries has been reported to be lower when used among Oriental populations. Diagnostic accuracy of two serological kits [HM-CAP and HM-CAP with antigens extracted from clinically isolated Japanese H. pylori strains (J-HM-CAP)] was investigated in 440 samples from a Japanese patient population by using the 13C-urea breath test as gold standard. According to the original optimal cut-off value, HM-CAP provided 87.5 % sensitivity and 84.8 % specificity with 86.8 % accuracy and J-HM-CAP provided 95.5 % sensitivity and 81.9 % specificity with 92.3 % accuracy. This study suggests that antigens from HM-CAP are satisfactory for examining a Japanese patient population, but that using local antigens improves accuracy.

Abbreviations: EV, ELISA value; ROC, receiver operator characteristic.




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