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J. Med. Microbiol. -- Vol. 51 (2002), 672-676
© 2002 Society for General Microbiology
ISSN 0022-2615

MYCOLOGY

Cytokine expression induced by Candida albicans in a model of cutaneous candidosis based on reconstituted human epidermis

MARTIN SCHALLER, REINHARD MAILHAMMER* and HANS.C. KORTING

Department of Dermatology and Allergology, University of Munich and *Institute of Clinical Molecular Biology and Tumor Genetics, GSF-National Research Center for Environment and Health, Munich, Germany

Corresponding author: Dr M. Schaller (e-mail: Martin.Schaller{at}lrz.uni-muenchen.de).

Received 3 Dec. 2001; revised version accepted 18 Feb. 2002.

Abstract

Skin equivalents based on reconstituted human epidermis have been used recently to establish models for allergic/irritant contact dermatitis and cutaneous candidosis. In the present study the cytokine expression pattern and the morphological alterations in experimental cutaneous candidosis were investigated by RT-PCR and histological analysis. In experimental cutaneous C. albicans infection the mRNA expression levels of interleukin (IL)-1{alpha}, IL-1ß, IL-8, GM-CSF, Exodus-2, tumour necrosis factor-{alpha} and PSL (P-selectin ligand) were upregulated. Cytokine profile and histological features of infected skin (separation of keratinocytes, oedema, vacuolisation) were comparable to that seen in experimental contact dermatitis. These immunomodulatory and morphological similarities might reflect a common pathogenesis factor in both diseases.




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