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J. Med. Microbiol. -- Vol. 51 (2002), 832-836
© 2002 Society for General Microbiology
ISSN 0022-2615

HOST RESPONSE TO INFECTION

NADH-oxidase, NADPH-oxidase and myeloperoxidase activity of visceral leishmaniasis patients

PROMOD KUMAR, KALPANA PAI*, HAUSHILA P. PANDEY and SHYAM SUNDAR*

Department of Biochemistry, Faculty of Science, Banaras Hindu University and *Department of Medicine, Institute of Medical Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi- 221005, India

Corresponding author: Professor S. Sundar (e-mail: shyam_vns{at}satyam.net.in).

Received 6 Feb. 2001; revised version accepted 23 May 2002.

It is believed that the enhanced capability of activated macrophages to resist infection is related to the remarkable increase in the production of oxygen metabolites in response to phagocytosis. Both the production of H2O2 and the oxidation of NAD(P)H are directly dependent upon NAD(P)H-oxidase. It has been established that the respiratory burst is due to activation of NAD(P)H-oxidase localised in the plasmalemma. Myeloperoxidase is believed to be involved in augmenting the cytotoxic activity of H2O2. Low NADH-oxidase, NADPH-oxidase and myeloperoxidase activity were observed in monocytes of patients with active visceral leishmaniasis as compared with healthy controls. These results suggest that low NADH-oxidase, NADPH-oxidase and myeloperoxidase activities may account for persistence of Leishmania parasites in visceral leishmaniasis.




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